LSD1-IN-43 is a highly selective, reversible, orally active and brain-penetrant LSD1 inhibitor with an IC50 value of 0.8 µM. LSD1-IN-43 has low inhibitory activity against MAO-A and MAO-B, two homologs of LSD1. LSD1-IN-43 significantly inhibits Abeta aggregation and enhances Abeta-induced neuronal cell viability. LSD1-IN-43 can be used for the study of Alzheimers disease (AD)[1].
Molecular Weight:
377.43
Formula:
C23H23NO4
Target:
Amyloid-beta,Histone Demethylase
Application Notes:
MCE Product type: Reference compound
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