AH001 is a orally active RhoA inhibitor, which binds a cryptic pocket proximate to GDP within RhoA with a KD of 73.16 nM. AH001 interacts with GDP, stabilizing RhoAs interaction with its endogenous inhibitor, RhoGDIalpha. AH001 reduces the downstream MRTFA nuclear translocation and downregulates fibrosis/hypertrophy proteins. AH001 mitigates myocardial remodeling in multiple HF animal models, and in the 3D myocardial tissue model. AH001 exerts its cardioprotective effects through the RhoA-RhoGDIalpha axis, effectively inhibiting downstream RhoA activation signaling[1].
Molecular Weight:
166.22
CAS Number:
[1456769-95-1]
Formula:
C10H14O2
Target:
Ras
Application Notes:
MCE Product type: Reference compound1
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