VS1150 (Compound 11) is a BCR-ABL-targeting phosphorylation-inducing chimeric small molecule (PHICS). VS1150 significantly inhibits oncogenic kinase BCR-ABL signaling by inducing inhibitory phosphorylation at its Y253 (EC50: 69 nM), subsequently triggering cell apoptosis. VS1150 also inhibits other oncogenic ABL fusions and drug-resistant mutants like T315I. VS1150 can be used for chronic myeloid leukemia (CML) and other ABL fusion-driven cancers research[1].
Molecular Weight:
844.58
CAS Number:
[2855238-97-8]
Formula:
C36H38Cl4N12O4
Target:
Apoptosis,Bcr-Abl,Caspase,ERK,PARP,STAT
Application Notes:
MCE Product type: Reference compound1
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