OXPHOS-IN-2 is an orally active OXPHOS inhibitor. OXPHOS-IN-2 exhibits potent inhibitory activity in PC9 (IC50 = 12.3 nM) and Bxpc-3 cells (IC50 = 250 nM in glucose medium, IC50 = 17.5 nM in galactose medium). OXPHOS-IN-2 decreases the NADH/NAD+ ratio and reduces ATP levels. OXPHOS-IN-2 induces tumor cells apoptosis by activating reactive oxygen species (ROS) and downregulating the level of Nrf2. OXPHOS-IN-2 can be used for research on cancer such as non-small cell lung cancer and pancreatic cancer[1].
Molecular Weight:
588.60
Formula:
C27H27F3N6O4S
Target:
AMPK,Apoptosis,Keap1-Nrf2,Mitochondrial Metabolism,Oxidative Phosphorylation,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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