Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of MrgX2 receptor with an IC50 value of 0.042-2.5 nM. Mrgx2 antagonist-3 blocks downstream G protein signaling and beta-Arrestin recruitment, thereby inhibiting MrgX2 receptor-mediated calcium influx and cellular degranulation. Mrgx2 antagonist-3 is promising for research of inflammation-related diseases and pruritus, such as chronic urticaria, allergic asthma[1].
Molecular Weight:
291.30
Purity:
98.09
CAS Number:
[2641397-91-1]
Formula:
C15H15F2N3O
Target:
Mas-related G-protein-coupled Receptor (MRGPR)
Application Notes:
MCE Product type: Reference compound
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