ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Target protein ligand (HY-176467), CRBN ligase (HY-41547), Linker (HY-176469), CRBN ligase + Linker (HY-176470))[1].
Molecular Weight:
884.03
CAS Number:
[3087879-97-5]
Formula:
C49H57N9O7
Target:
MDM-2/p53,PROTACs,Small Interfering RNA (siRNA)
Application Notes:
MCE Product type: Reference compound
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