FGFR2/3-IN-3, CAS [[3069945-78-1]] Preis auf Anfrage

Product Overview

• Article Name: FGFR2/3-IN-3, CAS [[3069945-78-1]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-176547
• Supplier Catalog Number: HY-176547
• Alternative Catalog Number: MCE-HY-176547-1UNIT
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

FGFR2/3-IN-3 is a dual-target FGFR2/3 inhibitor with IC50s of 2.7 nM (TEL-FGFR2) and 3.9 nM (TEL-FGFR3), respectively. FGFR2/3-IN-3 has effective activity against both wild-type and mutant FGFR3. FGFR2/3-IN-3 has low CYP3A4 inhibitory effect and hERG toxicity. FGFR2/3-IN-3 improves the imbalance between chondrocyte proliferation and differentiation and promotes bone growth by inhibiting the signaling pathway mediated by mutant FGFR3. FGFR2/3-IN-3 shows a growth-promoting effect in a dwarfism mouse model and has the potential to study bone development disorder-related diseases such as achondroplasia (ACH)[1].

Product Properties

• Molecular Weight: 569.46
• CAS Number: [3069945-78-1]
• Formula: C28H27Cl2FN6O2
• Target: Cytochrome P450,FGFR

Application Notes

• Application Notes: MCE Product type: Reference compound