ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research[1].
Molecular Weight:
499.86
Purity:
98.00
CAS Number:
[1787243-08-6]
Formula:
C23H29Cl3N4O2
Target:
Sodium Channel
Application Notes:
MCE Product type: Reference compound
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