NCI677397 is a USP24 inhibitor. NCI677397 increases lipid ROS, activates cholesterol and fatty acid biosynthesis, degrades ABC transporters, GPX4 and DHFR through the autophagy pathway, decreases the level of P-gp and ultimately leads to ferroptosis in drug-resistant cancer cells. NCI677397 can be used for the study of lung caner and brain cancer[1][2].
Molecular Weight:
457.63
CAS Number:
[907547-06-2]
Formula:
C28H31N3OS
Target:
Autophagy,Deubiquitinase,Ferroptosis,Glutathione Peroxidase,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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