KWZY-11 (Compound 11) is a potent PARP/CDK6 dual inhibitor with IC50 values of 156.8, 197.3, and 13.3 nM for PARP1, PARP2, and CDK6, respectively. KWZY-11 inhibits tumor cell proliferation by regulating the Wnt/beta-catenin signaling pathway. KWZY-11 induces excessive DNA damage and apoptosis in MDA-MB-231 breast cancer cells[1].
Molecular Weight:
543.02
CAS Number:
[3077131-44-0]
Formula:
C28H27ClN8O2
Target:
Apoptosis,CDK,PARP,Wnt,beta-catenin
Application Notes:
MCE Product type: Reference compound
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