GPX4-IN-17 (Compound 9i) is an inhibitor of GPX4 with potent cytotoxicity (IC50 = 0.3 nM). GPX4-IN-17 shows strong binding affinity against GPX4 (KD = 20.4 nM). GPX4-IN-17 inhibits tumor growth in the xenograft tumor mouse model without detectable cytotoxicity. GPX4-IN-17 can enhance cancer chemotherapy and overcome tumor resistance. GPX4-IN-17 can be studied in antitumor reseach[1].
Molecular Weight:
540.66
CAS Number:
[3035800-33-7]
Formula:
C29H24N4O3S2
Target:
Glutathione Peroxidase
Application Notes:
MCE Product type: Reference compound
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