KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance[1].
Molecular Weight:
765.06
CAS Number:
[2376747-46-3]
Formula:
C38H61FN6O5S2
Target:
Apoptosis,Caspase,Sec61
Application Notes:
MCE Product type: Reference compound
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