Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC)[1].
Molecular Weight:
1013.05
Purity:
98.01
CAS Number:
[606967-53-7]
Formula:
C48H64N6O18
Target:
Drug Derivative
Application Notes:
MCE Product type: ADC Related
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