PNR-3-80 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.67 µM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a potent cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin (HY-17394) and Docetaxel (HY-B0011)-induced cell death and represses Etoposide (HY-13629)-induced DNA damage and autophagy. PNR-3-80 can be used for cell injuries research[1][2].
Molecular Weight:
459.90
CAS Number:
[1424353-63-8]
Formula:
C24H14ClN3O3S
Target:
Endonuclease
Application Notes:
MCE Product type: Reference compound
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