GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBalpha with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1beta-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases[1].
Molecular Weight:
396.87
Purity:
96.38
CAS Number:
[2986733-57-5]
Formula:
C21H21ClN4O2
Target:
REV-ERB
Application Notes:
MCE Product type: Reference compound
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