Rodin-A is an orally active, brain-penetrant and selective histone deacetylase (HDAC)-co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 1.80 µM for the CoREST complex, 0.15 µM for HDAC1, and 0.43 µM for HDAC2. Rodin-A increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-A is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimers disease[1].
Molecular Weight:
352.41
CAS Number:
[2222756-46-7]
Formula:
C17H16N6OS
Target:
HDAC
Application Notes:
MCE Product type: Reference compound
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