RSC-1255 is a potent and selective Vacuolar H-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a Kd = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRASG13D and KRASG12V cells. RSC-1255 blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers[1].
Molecular Weight:
564.96
CAS Number:
[2171015-78-2]
Formula:
C27H25ClF4N4O3
Target:
Apoptosis,Autophagy,Proton Pump,Ras
Application Notes:
MCE Product type: Reference compound
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