AGF347 is a potent and multi-targeted antifolate that targets serine hydroxymethyltransferase (SHMT)2 in the mitochondria and SHMT1 in the cytosol, and inhibits de novo purine biosynthesis. AGF347 induces apoptosis, inhibits mTOR signaling, decreases GSH pools, and increases ROS. AGF347 inhibits proliferation of Cisplatin (HY-17394) sensitive and resistant epithelial ovarian cancer (EOC) cells. AGF347 exhibits antitumor efficacy in SKOV3 EOC xenograft mouse models. AGF347 can be used for ovarian cancer research[1][2].
Molecular Weight:
473.45
CAS Number:
[2294820-23-6]
Formula:
C22H24FN5O6
Target:
Antifolate,Apoptosis,Mitochondrial Metabolism,mTOR,Reactive Oxygen Species (ROS),SHMT
Application Notes:
MCE Product type: Reference compound
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