Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM. Mesutoclax has weak activity against BCL-XL (IC50: >1000 nM). Mesutoclax can inhibit the activity of RS4,11 cells with an IC50 of 2.75 nM. Mesutoclax can be used in the study of cancer[1].
Molecular Weight:
884.44
CAS Number:
[2760536-87-4]
Formula:
C45H50ClN7O8S
Target:
Bcl-2 Family
Application Notes:
MCE Product type: Reference compound
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