TLR7/8 agonist 13, CAS [[1402802-45-2]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-177300
Supplier Catalog Number:
HY-177300
Alternative Catalog Number:
MCE-HY-177300-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 µM) and TLR8 (LEC [hTLR8] = 1.6 µM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 µM). TLR7/8 agonist 13 induces endogenous IFNalpha, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNgamma, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus[1].
