IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 µM and 0.97 µM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-kappaB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1].
Molecular Weight:
399.87
Purity:
99.86
CAS Number:
[1356013-27-8]
Formula:
C20H22ClN5O2
Target:
IRAK,JAK,NF-kappaB,STAT
Application Notes:
MCE Product type: Reference compound
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