TD-522 is a potent and selective molecular glue GSPT1 degrader, with a DC50 of 0.269 nM. TD-522 exhibits strong anti-proliferative effects and induces apoptosis in acute myeloid leukemia (AML) and diffuse large B-cell lymphoma (DLBCL) cells. TD-522 suppresses tumor growth in a TMD-8 xenograft model. TD-522 can be used for AML and DLBCL research[1].
Molecular Weight:
510.97
CAS Number:
[2417647-40-4]
Formula:
C25H27ClN6O4
Target:
Apoptosis,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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