iDeg-6 is a selective molecular glue degrader that targets IDO1 with a DC50 of 6.5 nM. iDeg-6 can competitively bind to the heme binding site of apo-IDO1, preventing heme binding and inhibiting the enzymatic reaction that converts tryptophan into kynurenine by IDO1 (IC50 = 1.6 µM). iDeg-6 can be used for the researches of cancer, infection and neurological disease, such as melanoma[1].
Molecular Weight:
548.74
Formula:
C32H40N2O4S
Target:
Indoleamine 2,3-Dioxygenase (IDO),Molecular Glues
Application Notes:
MCE Product type: Reference compound
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