DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 µM and 4.6 µM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer[1].
Molecular Weight:
512.96
CAS Number:
[1620225-37-7]
Formula:
C25H21ClN2O6S
Target:
Kinesin
Application Notes:
MCE Product type: Reference compound
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