NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 µM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research[1].
Molecular Weight:
374.35
CAS Number:
[951950-33-7]
Formula:
C17H18N4O6
Target:
NEDD8-activating Enzyme
Application Notes:
MCE Product type: Reference compound
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