GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research[1].
Molecular Weight:
474.53
Purity:
98.83
CAS Number:
[3052947-04-0]
Formula:
C25H22N4O4S
Target:
G Protein-coupled Receptor Kinase (GRK)
Application Notes:
MCE Product type: Reference compound
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