NV914 is an inhibitor of FTSJ1 (tryptophan tRNA-specific 2-O-methyltransferase) that inhibits the methyltransferase activity of FTSJ1, induces translational readthrough of premature termination codons, and enables genes carrying nonsense mutations to synthesize full-length proteins. NV914 belongs to translational readthrough-inducing compounds (TRIDs). NV914 exhibits translational readthrough activity against nonsense mutations in in vitro systems, does not induce readthrough of natural termination codons, and restores CFTR protein expression. NV914 shows favorable acute oral tolerance in mice, with low health risks and good safety profiles. NV914 is applicable to research related to cystic fibrosis and Shwachman-Diamond syndrome[1][2][3].
Molecular Weight:
445.18
Purity:
98.98
CAS Number:
[2341941-41-9]
Formula:
C15HF10N3O2
Target:
DNA Methyltransferase
Application Notes:
MCE Product type: Reference compound
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