EGFR-IN-175 is an orally active and selective EGFRL858R/T790M/C797S inhibitor with an IC50 of 18.94 nM. EGFR-IN-175 can induce cell apoptosis and cause G1 phase arrest. EGFR-IN-175 can downregulate p-EGFR, p-AKT, and p-ERK expression. EGFR-IN-175 can be used for the research of cancer, such as lung cancer[1].
Molecular Weight:
702.85
Formula:
C33H38N10O4S2
Target:
Akt,Apoptosis,EGFR,PERK
Application Notes:
MCE Product type: Reference compound
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