GLPG4471 is a selective and orally active IRAK4 inhibitor with an IC50 of 1.7 nM. GLPG4471 exhibits potent inhibition of cytokine (TNFalpha and IFNalpha) secretion in cellular and whole blood phenotypic assays. GLPG4471 displays significant activity in a mouse model of collagen-induced arthritis. GLPG4471 can be used for the study of arthritis[1].
Molecular Weight:
410.47
CAS Number:
[2499855-36-4]
Formula:
C22H26N4O4
Target:
IRAK,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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