RSK2/TOP2-IN-1 is a RSK2/TOP2 dual inhibitor. RSK2/TOP2-IN-1 targets key tumor progression enzymes including ribosomal S6 kinase 2 and topoisomerases IIalpha/IIbeta. RSK2/TOP2-IN-1 shows selectivity index > 2 against all squamous cell carcinoma (SCC) cell lines. RSK2/TOP2-IN-1 can induce cell apoptosis, autophagy and ROS production. RSK2/TOP2-IN-1 can be used for the research of cancer, such as squamous cell carcinoma[1].
Molecular Weight:
518.64
Formula:
C29H26O5S2
Target:
Apoptosis,Autophagy,Reactive Oxygen Species (ROS),Ribosomal S6 Kinase (RSK),Topoisomerase
Application Notes:
MCE Product type: Reference compound
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