PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells[1]. Pink: OSBP ligand (HY-178035), Blue: CRBN ligase ligand (HY-10984), Black: linker
Molecular Weight:
1017.17
Formula:
C56H68N6O12
Target:
Oxysterol-binding Protein-related Protein (ORP),PROTACs
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
