UM-242 is a STING inhibitor, with an EC50 of 1.70 µM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNbeta and IL6 and reducing IFNbeta secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases[1].
Molecular Weight:
536.45
Formula:
C24H18F2N8O5
Target:
IFNAR,Interleukin Related,STING
Application Notes:
MCE Product type: Reference compound
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