UM-259 is a STING inhibitor, with an EC50 of 1.50 µM in THP1-Dual cells expressing wild-type STING. UM-259 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNbeta and IL6 and reducing IFNbeta secretion. UM-259 can be used for the study of STING-dependent inflammatory and neurological diseases[1].
Molecular Weight:
561.50
Formula:
C27H21F2N7O5
Target:
IFNAR,Interleukin Related,STING
Application Notes:
MCE Product type: Reference compound
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