LMDP10 is an orally active 3-amino quinazoline derivative with Keap1-Nrf2 pathway activation activity. LMDP10 binds to Keap1 to inhibit Keap1-Nrf2 interaction, thereby activating the Nrf2 pathway. LMDP10 elevates Nrf2, SOD, and GSH levels, reduces MDA and TNF-alpha levels, attenuates neurodegeneration, and improves memory function in Alzheimers disease (AD) rats. LMDP10 can be used for the study of AD[1].
Molecular Weight:
492.50
CAS Number:
[2760446-25-9]
Formula:
C29H21FN4O3
Target:
Drug Derivative,Keap1-Nrf2
Application Notes:
MCE Product type: Reference compound
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