EGFR-IN-176, CAS [[2754394-10-8]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178057
Supplier Catalog Number:
HY-178057
Alternative Catalog Number:
MCE-HY-178057-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
EGFR-IN-176 is an orally active and ATP-competitive EGFR mutant inhibitor (particularly C797S-mediated EGFR triple mutant). EGFR-IN-176 effectively inhibits subsequent AKT signaling and induces apoptosis in Ba/F3 and PC-9 cells expressing EGFR19del/T790M/C797S and EGFRL858R/T790M/C797S. EGFR-IN-176 selectively inhibits EGFR signaling in cell lines harboring EGFR triple mutation and shows no inhibitory effect against A431 cells that express wild-type EGFR. EGFR-IN-176 can effectively inhibit the enzymatic activity of ALK (IC50 [1].
