FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 µM and causes FPR2 desensitization with an IC50 of 0.32 µM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1beta, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases[1].
