SA91-0178 is a METTL1 inhibitor. SA91-0178 inhibits m7G methylation of RNA, reduces SARM1 stability, mitigates NAD+ depletion and metabolic reprogramming in macrophages. SA91-0178 demonstrates excellent protective efficacy against multiple organ injury in cecal ligation and puncture (CLP)-induced and ischemia/reperfusion (I/R)-induced mice. SA91-0178 can be used for the study of systemic inflammatory diseases[1].
Molecular Weight:
469.53
CAS Number:
[2244341-81-7]
Formula:
C28H27N3O4
Target:
RNA MTase
Application Notes:
MCE Product type: Reference compound
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