Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE, CAS [[3103526-19-5]] Preis auf Anfrage

Product Overview

• Article Name: Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE, CAS [[3103526-19-5]] Preis auf Anfrage
• Biozol Catalog Number: MCE-HY-178219
• Supplier Catalog Number: HY-178219
• Alternative Catalog Number: MCE-HY-178219-5MG,MCE-HY-178219-25MG,MCE-HY-178219-50MG,MCE-HY-178219-10MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE contains a linker and bioactive small molecule toxins MMAE (HY-15162). Bis-sulfone-(PEG24)-Glu-Val-Cit-PAB-MMAE can conjugate with NN2101 (HY-P991293) (anti c-Kit) for synthesizing NN3201. NN3201 rapidly internalizes and inhibits SCF-driven signaling, thereby delivering its payload to induce cell cycle arrest and apoptosis. NN3201 exhibits significant c-Kit-dependent anti-tumor efficacies in various tumor models, such as small cell lung cancer (SCLC) and gastrointestinal stromal tumor (GIST)[1].

Product Properties

• Molecular Weight: 2805.41
• Purity: 97.88
• CAS Number: [3103526-19-5]
• Formula: C137H222N12O44S2
• Target: Apoptosis,Drug-Linker Conjugates for ADC,Microtubule/Tubulin

Application Notes

• Application Notes: MCE Product type: Reference compound