UNC10088 is a molecular glue targeting NSD2. UNC10088 mediates the formation of a stable ternary complex between SCFFBXO22 and the NSD2 PWWP1 domain. UNC10088 promotes ubiquitination of the SCFFBXO22-dependent NSD2 PWWP1 domain through reversible covalent bonding with the C326 region of FBXO22. UNC10088 could be used in cancer research[1].
Molecular Weight:
712.74
Formula:
C35H37N4NaO9S
Target:
Histone Methyltransferase,Molecular Glues
Application Notes:
MCE Product type: Reference compound
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