T2M-010 is a potent, brain-penetrant TREM2 agonist (Kd = 0.83 µM). T2M-010 activates receptor-proximal signaling, inducing SYK phosphorylation in TREM2-expressing cells, and promotes microglial phagocytosis. T2M-010 can be used for the study of protective microglial responses relevant to Alzheimers disease (AD)[1].
Molecular Weight:
319.42
CAS Number:
[364611-21-2]
Formula:
C19H17N3S
Target:
Syk,TREM receptor
Application Notes:
MCE Product type: Reference compound
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