VDR agonist 4 is an orally active potent VDR agonist. VDR agonist 4 exerts VDR-dependent antifibrotic activity by regulating multiple fibrosis-related genes to suppress alpha-SMA and collagen I production, thereby inhibiting hepatic stellate cell (HSC) activation. VDR agonist 4 improves CCl4 (HY-RS16594)-induced hepatic fibrosis in mice. VDR agonist 4 can be used for liver fibrosis research[1].
Molecular Weight:
471.59
Formula:
C27H37NO6
Target:
Collagen,JAK,MMP,TGF-beta/Smad,VD/VDR
Application Notes:
MCE Product type: Reference compound
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