AC-340 is a potent hybrid VDR agonist/HDAC inhibitor. AC-340 superinduces VDR target genes (e.g., CYP24A1) and inhibits HDAC6 (IC50 = 0.37 µM) with ~10-fold selectivity over HDAC2. AC-340 induces VDR hyperagonism by causing widespread protein hyperacetylation (e.g., tubulin and H3K9/K27), which leads to elevated H3K27 acetylation on VDR target genes. AC-340 can be used for melanoma cancer research[1].
Molecular Weight:
476.67
Formula:
C26H40N2O4S
Target:
HDAC,Microtubule/Tubulin,VD/VDR
Application Notes:
MCE Product type: Reference compound
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