Aurora A-IN-5 is a potent and highly selective Aurora A inhibitor (IC50 = 0.02 µM), showing 362-fold selectivity for over Aurora B. Aurora A-IN-5 shows its selectivity through unique C-H/pi interactions, enhanced hydrophobic contacts, an open binding pocket, and tighter protein packing. Aurora A-IN-5 suppresses Aurora A autophosphorylation, thereby inhibiting cancer cell proliferation by inducing G2/M phase arrest, triggering apoptosis, and suppressing colony formation. Aurora A-IN-5 inhibits tumor growth in MDA-MB-231 xenograft mouse models. Aurora A-IN-5 can be used for breast, cervical, prostate, and lymphoma cancer research[1].
Molecular Weight:
459.54
Formula:
C25H29N7O2
Target:
Apoptosis,Aurora Kinase
Application Notes:
MCE Product type: Reference compound
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