MFDCH016 is a potent HDAC1/6 (IC50 = 38/59 nM) and CDK4/6 (IC50 = 680/720nM) inhibitor. MFDCH016 induces apoptosis and cell cycle arrest in G2/M and G0/G1 phases in MCF-7 cells. MFDCH016 can modulate the HDAC-p21-CDK signaling pathway, increasing the levels of acetylated H3 and p21. MFDCH016 can be used for the study of breast cancer[1].
Molecular Weight:
534.61
Formula:
C27H34N8O4
Target:
Apoptosis,CDK,HDAC,Histamine Receptor
Application Notes:
MCE Product type: Reference compound
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