HDAC6-IN-67, CAS [[2196247-20-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-178351
Supplier Catalog Number:
HY-178351
Alternative Catalog Number:
MCE-HY-178351-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
HDAC6-IN-67 is a selective HDAC6 inhibitor (IC50 = 17.15 nM) that exhibits 19-fold selectivity over HDAC1. HDAC6-IN-67 selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by inducing the cleavage of caspases 9, 8, 3, and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. HDAC6-IN-67 effectively induces the acetylation of alpha-tubulin, without affecting histone H3 acetylation in MCF-7/ADR cells. HDAC6-IN-67 can be used for the study of breast cancer[1].
