EGFR/Cytokine-IN-1 is an EGFR (IC50 = 0.03 µM) and Cytokine inhibitor (TNF-alpha, IC50 = 3.1 µM, IL-6, IC50 = 1.6 µM). EGFR/Cytokine-IN-1 shows potent anticancer activity on A549 and MCF7, respectively. EGFR/Cytokine-IN-1 significantly reduces IL-6 and TNF-alpha levels in A549 cells, and also shows promising ADMET profiles. EGFR/Cytokine-IN-1 can induce apoptosis in a dose-dependent manner. compound 5h can be used for the study of breast cancer and lung cancer[1].
Molecular Weight:
499.94
Formula:
C28H22ClN3O4
Target:
Apoptosis,EGFR,Interleukin Related,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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