BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 µM) and SARS-CoV-2 Mpro (IC50 = 0.91 µM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimers disease[1].
Molecular Weight:
431.49
Formula:
C28H21N3O2
Target:
Beta-secretase,SARS-CoV
Application Notes:
MCE Product type: Reference compound
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