HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia[1].
Molecular Weight:
628.55
Formula:
C37H27Cl2N5O
Target:
Apoptosis,Bcl-2 Family,Biochemical Assay Reagents,Caspase,HDAC,Necroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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