TRPM2-IN-2 is a potent and selective TRPM2 inhibitor (IC50 = 0.66 µM) with minimal activity against TRPM8 and TRPV1 (IC50 >10 µM). TRPM2-IN-2 exhibits robust neuroprotective effects in both in vitro oxygen-glucose deprivation/reperfusion (OGD/R) model and in vivo transient middle cerebral artery occlusion (tMCAO) mouse model. TRPM2-IN-2 can be used for ischemic stroke research[1].
Molecular Weight:
391.51
Formula:
C24H29N3O2
Target:
TRP Channel
Application Notes:
MCE Product type: Reference compound
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