SHMT2-IN-1 is a potent serine hydroxymethyltransferase 2 (SHMT2) inhibitor with an IC50 of 1.21 µM and a KD of 10.6 µM. SHMT2-IN-1 binds to the folate binding site of SHMT2. SHMT2-IN-1 also inhibits SHMT1 with an IC50 of 1.83 µM. SHMT2-IN-1 can inhibit cancer cells proliferation, migration and invasion. SHMT2-IN-1 can induce cells apoptosis and ROS production and cause G2/M phase arrest. SHMT2-IN-1 can be used for the research of cancer, such as esophageal cancer[1].
Molecular Weight:
558.03
Formula:
C26H16ClN7O2S2
Target:
Apoptosis,Reactive Oxygen Species (ROS),SHMT
Application Notes:
MCE Product type: Reference compound
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